February 5, 2024

The Multifaceted Benefits of Rutin in Managing Diabetes

Posted on February 5, 2024  •  3 minutes  • 524 words  • Other languages:  Deutsch, Русский
Table of contents

Unveiling Rutin: A Natural Ally Against Diabetes

Diabetes, a global health challenge, continues to affect millions worldwide with its array of complications. In the search for effective treatments, natural compounds have garnered significant attention. One such compound, rutin, a flavonoid found in various plants like Fagopyrum esculentum, Ruta graveolens, and Sophora japonica, has shown promising potential in managing diabetes. Ahmad Ghorbani’s comprehensive review, “Mechanisms of antidiabetic effects of flavonoid rutin” in Biomedicine & Pharmacotherapy, 2017, delves into the multifaceted role of rutin in combating diabetes-related challenges.

Rutin’s Antidiabetic Properties: A Closer Look

The review by Ghorbani highlights the antihyperglycemic properties of rutin, demonstrating its ability to lower blood glucose levels and improve lipid profiles in diabetic models. Rutin achieves this through various mechanisms, such as inhibiting carbohydrate absorption from the small intestine, stimulating insulin secretion from beta cells, enhancing tissue glucose uptake, and inhibiting liver gluconeogenesis. These mechanisms collectively contribute to rutin’s effectiveness in managing hyperglycemia and dyslipidemia, core aspects of diabetes.

Rutin and Diabetic Complications: A Protective Shield

One of the most compelling aspects of rutin’s therapeutic profile is its protective effects against diabetic complications. Diabetes, characterized by chronic hyperglycemia and dyslipidemia, leads to numerous complications, including nephropathy, neuropathy, liver damage, and cardiovascular diseases. Rutin’s intervention in these complications is multifaceted. It decreases the formation of harmful substances like sorbitol, reactive oxygen species, and advanced glycation end-products, all of which contribute to the progression of diabetic complications.


In diabetic nephropathy, rutin shows promising results in reducing proteinuria and levels of blood urea nitrogen and serum creatinine, indicating improved kidney function. These effects are linked to rutin’s ability to reduce oxidative stress and AGE formation in renal tissues, pointing to its potential in managing one of the most significant microvascular complications of diabetes.


Rutin’s role in diabetic neuropathy is also noteworthy. It alleviates symptoms like hyperalgesia, allodynia, and motor coordination deficits in diabetic models. These benefits are attributed to rutin’s anti-inflammatory and antioxidant actions, which help mitigate nerve damage and improve nerve function.

Liver Damage

In the context of diabetic liver damage, rutin exhibits hepatoprotective properties. It reduces oxidative stress and histological damage in the liver, indicating its potential in preventing the progression of non-alcoholic steatohepatitis to cirrhosis, a serious complication in diabetic patients.

Cardiovascular Diseases

Rutin also plays a significant role in managing diabetes-induced cardiovascular complications. It helps reduce oxidative stress and inflammation, factors that contribute to vascular pathology in diabetes.

The Road Ahead: Clinical Implications and Future Research

While the experimental findings are promising, Ghorbani’s review also emphasizes the need for well-designed clinical trials to evaluate rutin’s efficacy and safety in human subjects. The review suggests that rutin has the potential to be a beneficial supplement in diabetes management, but further research is required to fully understand its therapeutic scope and limitations.


Rutin emerges as a versatile natural compound with significant potential in managing diabetes and its complications. Its multifaceted mechanisms of action, including antihyperglycemic, antioxidative, and anti-inflammatory properties, make it a promising candidate for further research and clinical application in diabetes care.


  1. Ghorbani, A. (2017). Mechanisms of antidiabetic effects of flavonoid rutin. Biomedicine & Pharmacotherapy, 96, 305–312.




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